Sphingolipids play a key role in cells as structural components of membrane lipid bilayers
and signaling molecules implicated in important physiological and pathological processes …

Drug-resistant microorganisms (DRMs) are generally thought to suffer from a fitness cost
associated with their drug-resistant trait, inflicting them a disadvantage when the drug …

Limited knowledge on the exact functions of ergostane‐based sterols has hampered the
application of sterol synthesis inhibitors against trypanosomatid parasites. Sterol …

Sterol biosynthesis is a crucial pathway in eukaryotes leading to the production of
cholesterol in animals and various C24-alkyl sterols (ergostane-based sterols) in fungi …

Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to
be closely linked in L eishmania donovani, with SSG‐resistant strains showing an increased …

Sterol 14-α-demethylase (C14DM) is a key enzyme in the biosynthesis of sterols and the
primary target of azoles. In Leishmania major, genetic or chemical inactivation of C14DM …

Many pathogens synthesize inositol phosphorylceramide (IPC) as the major sphingolipid
(SL), differing from the mammalian host where sphingomyelin (SM) or more complex SLs …

Phosphatidylcholine (PC) is the most abundant type of phospholipids in eukaryotes
constituting~ 30% of total lipids in Leishmania. PC synthesis mainly occurs via the choline …

The accessibility of sterols in mammalian cells to exogenous sterol-binding agents has been
well-described previously, but sterol accessibility in distantly related protozoa is unclear. The …

Abstract Background: In the Mediterranean region, Leishmania infantum is the main cause
of visceral leishmaniasis. Dogs with canine visceral leishmaniasis are an important reservoir …