Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

A small proportion of breast cancer, in particular those cases arising at a young age, is due
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A …

Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The
toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern …

Biologic machines need brakes, and the nature and fidelity of their operation cannot be
unraveled without some prior understanding of how accelerators work. The discoveD] of …

CYTOGENETIC abnormalities of chromosome 9p21 are characteristic of malignant
melanomas1, 2, gliomas3, lung cancers4 and leukaemias5. From a panel of 46 human …

Melanoma is the most deadly of the common skin cancers and its incidence is rapidly
increasing. Approximately 10% of cases occur in a familial context. To date, cyclin …

Eleven uveal melanomas were analyzed using comparative genomic hybridization (CGH).
The most abundant genetic changes were loss of chromosome 3, overrepresentation of 6p …