Stem cell biology has come of age. Unequivocal proof that stem cells exist in the
haematopoietic system has given way to the prospective isolation of several tissue-specific …

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

Why are tumours heterogeneous, in terms of cell phenotype and proliferative potential, even
in cases in which all cells are derived from a single clone? Ongoing mutagenesis can …

Satellite cells play a central role in mediating the growth and regeneration of skeletal
muscle. However, whether satellite cells are stem cells, committed progenitors, or …

Solid tumors arise in organs that contain stem cell populations. The tumors in these tissues
consist of heterogeneous populations of cancer cells that differ markedly in their ability to …

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion
during development. Studies of cell-fate determination in the vertebrate retina have …

The lining of the intestine is renewed at an extraordinary rate, outpacing all other tissues in
the vertebrate body. The renewal process is neatly organized in space, so that the whole …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …

Notch signalling participates in the development of multicellular organisms by maintaining
the self-renewal potential of some tissues and inducing the differentiation of others …

The molecular mechanisms mediating the retinogenic potential of multipotent retinal
progenitor cells (RPCs) are poorly defined. Prior to initiating retinogenesis, RPCs express a …