For almost a century, vitamin A has been known as a nutrient critical for normal
development, differentiation, and homeostasis; accordingly, there has been much interest in …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …

Stature is affected by many polymorphisms of small effect in humans. In contrast, variation in
dogs, even within breeds, has been suggested to be largely due to variants in a small …

The hormonal form of vitamin D 3, 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is an
immune system modulator and induces expression of the TLR coreceptor CD14. 1, 25 (OH) …

Summary Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2
and mediates mono-, di-, and trimethylation of histone H3 at lysine 27. At least two …

During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …

Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …