Apoptosis is characterised by a series of typical morphological features, such as shrinkage
of the cell, fragmentation into membrane-bound apoptotic bodies and rapid phagocytosis by …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

Exacerbation of hypoxic injury after restoration of oxygenation (reoxygenation) is an
important mechanism of cellular injury in transplantation and in myocardial, hepatic …

Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart
failure in rodent models. This death process is mediated by two central pathways, an …

Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-
mesenchymal transition, but whether cardiac fibroblasts can adopt an endothelial cell fate …

Coronary artery disease leads to injury and loss of myocardial tissue by deprivation of blood
flow (ischemia) and is a major underlying cause of heart failure. Prolonged ischemia causes …

Recent studies indicate that, in addition to necrosis, apoptosis also plays a role in the
process of tissue damage after myocardial infarction, which has pathological and …

Tissue engineering has enabled the development of advanced and physiologically relevant
models of cardiovascular diseases, with advantages over conventional 2D in vitro assays …

In recent years, the understanding that regeneration progresses at the level of the
myocardium has placed stem cell research at the center stage in cardiology. Despite an …

miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as
to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in …