Across all branches of the immune system, the process of autophagy is fundamentally
important in cellular development, function and homeostasis. Strikingly, this evolutionarily …

Bone homeostasis involves bone formation and bone resorption, which are processes that
maintain skeletal health. Oxidative stress is an independent risk factor, causing the …

Abstract N6‐methyladenosine (m6A) is an abundant nucleotide modification in mRNA,
known to regulate mRNA stability, splicing, and translation, but it is unclear whether it is also …

Punicalagin, a hydrolysable tannin of pomegranate juice, exhibits multiple biological effects,
including inhibiting production of pro-inflammatory cytokines in macrophages. Autophagy …

Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no
effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells …

Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …

Autophagy is a crucial recycling process that is increasingly being recognized as an
important factor in cancer initiation, cancer (stem) cell maintenance as well as the …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Bone metabolic disorders include osteolysis, osteoporosis, osteoarthritis and rheumatoid
arthritis. Osteoblasts and osteoclasts are two major types of cells in bone constituting …

Autophagy is an evolutionarily conserved catabolic process. Although the components of
autophagy in cytoplasm have been well-studied, the molecular basis for the epigenetic …