Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

Abstract Purpose of Review Coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health challenge. This …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Mitochondrial uncoupling can be defined as a dissociation between mitochondrial
membrane potential generation and its use for mitochondria-dependent ATP synthesis …

Mitochondria generate heat due to H+ leak (IH) across their inner membrane. IH results from
the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat,,,–and …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

Breakthrough technologies to measure cellular oxygen consumption and proton efflux are
reigniting the study of cellular energetics by increasing the scope and pace with which …

Small molecules are pharmacological tools of considerable value for dissecting complex
biological processes and identifying potential therapeutic interventions. Recently, the …

Mitochondrial division is essential for mitosis and metazoan development, but a mechanistic
role in cancer biology remains unknown. Here, we examine the direct effects of oncogenic …

Background: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor
malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for …