Viruses are ubiquitous parasites of cellular life and the most abundant biological entities on
Earth. It is widely accepted that viruses are polyphyletic, but a consensus scenario for their …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Homology modeling aims to build three-dimensional protein structure models using
experimentally determined structures of related family members as templates. SWISS …

Motivation Protein fold recognition is an important problem in structural bioinformatics.
Almost all traditional fold recognition methods use sequence (homology) comparison to …

While the number of sequenced genomes continues to grow, experimentally verified
functional annotation of whole genomes remains patchy. Structural genomics projects are …

Abstract PDBsum (http://www. ebi. ac. uk/pdbsum) provides summary information about
each experimentally determined structural model in the Protein Data Bank (PDB). Here we …

One of the most prominent features of archaea is the extraordinary diversity of their DNA
viruses. Many archaeal viruses differ substantially in morphology from bacterial and …

The bestselling introduction to bioinformatics and genomics–now in its third edition Widely
received in its previous editions, Bioinformatics and Functional Genomics offers the most …

Background Our first predictor of protein disorder was published just over a decade ago in
the Proceedings of the IEEE International Conference on Neural Networks (Romero P …

Genome-wide studies are providing researchers with a potentially complete list of the
molecular components present in living systems. It is now evident that several metal ions are …