Recent applications of 1, 3-thiazole core structure in the identification of new lead compounds and drug discovery

A Ayati, S Emami, A Asadipour, A Shafiee… - European Journal of …, 2015 - Elsevier
Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

Pharmacological significance of triazole scaffold

R Kharb, PC Sharma, MS Yar - Journal of enzyme inhibition and …, 2011 - Taylor & Francis
The triazole nucleus is one of the most important and well known heterocycles which is a
common and integral feature of a variety of natural products and medicinal agents. Triazole …

4-Thiazolidinones: the advances continue…

AC Tripathi, SJ Gupta, GN Fatima, PK Sonar… - European Journal of …, 2014 - Elsevier
The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …

5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry

D Kaminskyy, A Kryshchyshyn, R Lesyk - European journal of medicinal …, 2017 - Elsevier
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Antituberculosis drugs: ten years of research

YL Janin - Bioorganic & medicinal chemistry, 2007 - Elsevier
Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs

K Omar, A Geronikaki, P Zoumpoulakis… - Bioorganic & medicinal …, 2010 - Elsevier
As part of ongoing studies in develo** new antimicrobials, a class of structurally novel 4-
thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole …

Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1, 2, 4-triazole and 1, 3, 4-oxadiazoles as potential antimicrobial and antitubercular agents

GVS Kumar, Y Rajendraprasad, BP Mallikarjuna… - European journal of …, 2010 - Elsevier
In the present study a series of 2-substituted-5-[isopropylthiazole] clubbed 1, 2, 4-triazole
and 1, 3, 4-oxadiazole derivatives have been synthesized and characterized by IR, 1H NMR …

Clubbed [1, 2, 3] triazoles by fluorine benzimidazole: a novel approach to H37Rv inhibitors as a potential treatment for tuberculosis

C Gill, G Jadhav, M Shaikh, R Kale, A Ghawalkar… - Bioorganic & Medicinal …, 2008 - Elsevier
A Novel Clubbed [1, 2, 3] triazoles with fluorine benzimidazole series of H37Rv strain
inhibitors, potentially useful for the treatment of tuberculosis is disclosed on the basis of …

TMC207: the first compound of a new class of potent anti-tuberculosis drugs

A Matteelli, ACC Carvalho, KE Dooley… - Future …, 2010 - Taylor & Francis
Disease caused by Mycobacterium tuberculosis continues as a global epidemic: over 2
billion people harbor latent TB infection, and more than 9 million new TB cases, of whom …

Schiff bases of indoline-2, 3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building

T Aboul-Fadl, FAS Bin-Jubair, O Aboul-Wafa - European journal of …, 2010 - Elsevier
Tuberculosis (TB) remains among the world's great public health challenges. Worldwide
resurgence of TB is due to two major problems: the AIDS epidemic, which started in the mid …