The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Several attempts have been made to treat Alzheimer's disease (AD) using anti-amyloid
strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone …

The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide
in the brain is a central event in Alzheimer's disease pathology, has dominated research for …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

We recommend a new term,“primary age-related tauopathy”(PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

This report describes the first human study of a novel amyloid‐imaging positron emission
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with …

Automated analysis of MRI data of the subregions of the hippocampus requires
computational atlases built at a higher resolution than those that are typically used in current …

Assessment of Alzheimer's disease (AD)-related neurofibrillary pathology requires a
procedure that permits a sufficient differentiation between initial, intermediate, and late …

Hepatocellular carcinoma (HCC) is a major global health problem. In the year 2000, HCC
was the third leading cause of cancer-related death worldwide, accounting for over half a …

The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …