Clonal heterogeneity and tumor evolution: past, present, and the future
Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …
medicine. Here, we review data and technologies that have revealed intra-tumor …
The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
Clonal expansion in non-cancer tissues
N Kakiuchi, S Ogawa - Nature Reviews Cancer, 2021 - nature.com
Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …
Mechanisms of Polycomb group protein function in cancer
V Parreno, AM Martinez, G Cavalli - Cell research, 2022 - nature.com
Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
Pediatric gliomas: current concepts on diagnosis, biology, and clinical management
Gliomas are the most common CNS tumors in children and adolescents, and they show an
extremely broad range of clinical behavior. The majority of pediatric gliomas present as …
extremely broad range of clinical behavior. The majority of pediatric gliomas present as …
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
Characteristics of H3 K27M-mutant gliomas in adults
D Meyronet, M Esteban-Mader, C Bonnet… - Neuro …, 2017 - academic.oup.com
Abstract Background. Diffuse H3 K27M-mutant gliomas occur primarily in children but can
also be encountered in adults. The aim of this study was to describe the characteristics of H3 …
also be encountered in adults. The aim of this study was to describe the characteristics of H3 …
H3. 3K27M cooperates with Trp53 loss and PDGFRA gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas
Gain-of-function mutations in histone 3 (H3) variants are found in a substantial proportion of
pediatric high-grade gliomas (pHGG), often in association with TP53 loss and platelet …
pediatric high-grade gliomas (pHGG), often in association with TP53 loss and platelet …
Functionalized macrophage exosomes with panobinostat and PPM1D‐siRNA for diffuse intrinsic pontine gliomas therapy
S Shan, J Chen, Y Sun, Y Wang, B **a, H Tan… - Advanced …, 2022 - Wiley Online Library
Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of
p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell …
p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell …