Objectives The first drug repurposed for the treatment of depression was the tuberculostatic
iproniazid. At present, drugs belonging to new classes of antidepressants still have …

Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie addiction
behaviors. Evidence suggests glial cells have an essential and underappreciated role in the …

Microglia, the tissue-resident macrophages of the central nervous system (CNS), have
characterized roles in combating infection, clearing cellular debris, and maintaining tissue …

Ectopic discharge in axotomized dorsal root ganglion neurons is a key driver of neuropathic
pain. However, the bulk of this activity is generated and carried centrally in large diameter …

Glutamate is the major excitatory neurotransmitter in the brain and may be a key
neurotransmitter involved in autism. Literature pertaining to glutamate and autism or related …

Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically
available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective …

In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …

Mood disorders are marked by high rates of non-recovery, recurrence, and chronicity, which
are insufficiently addressed by current therapies. Several patho-etiological models have …

The absence of selective pharmacological tools is a major barrier to the in vivo study of
microglia. To address this issue, we developed a G q-and G i-coupled Designer Receptor …

Chronic pain relief remains an unmet medical need. Current research points to a substantial
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …