Telomere maintenance is essential for maintaining genome integrity in both normal and
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …

Cancer cells acquire replicative immortality by activating a telomere maintenance
mechanism (TMM), either the telomerase or the Alternative Lengthening of Telomeres (ALT) …

Although CDKN2A is the most frequent high-risk melanoma susceptibility gene, the
underlying genetic factors for most melanoma-prone families remain unknown. Using whole …

Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative
barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long …

MicroRNAs (miRNAs) have a critical role in tumorigenesis and metastasis, which are major
obstacles of cancer therapy. However, the role of miRNAs in colorectal cancer (CRC) …

Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-
derived tissues, but not in neural lineages, a consequence of telomere dysfunction and …

The discovery that rare POT1 variants are associated with extremely long telomeres and
increased cancer predisposition has provided a framework to revisit the relationship …

SLX4 assembles a toolkit of endonucleases SLX1, MUS81 and XPF, which is recruited to
telomeres via direct interaction of SLX4 with TRF2. Telomeres present an inherent obstacle …

Limitless reproductive potential is one of the hallmarks of cancer cells. This ability is due to
the maintenance of telomeres, erosion of which causes cellular senescence or death. While …

Aging, cancer, and chronic disease have remained at the forefront of basic biological
research for decades. Within this context, significant attention has been paid to the role of …