Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

Familial adenomatous polyposis (FAP) is an autosomal-dominant colorectal cancer
syndrome, caused by a germline mutation in the adenomatous polyposis coli (APC) gene …

Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …

Background: Familial adenomatous polyposis (FAP) is a well-described inherited syndrome,
which is responsible for< 1% of all colorectal cancer (CRC) cases. The syndrome is …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

BACKGROUND Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although
rare in the general population, they are a common extracolonic manifestation of familial …

Sarcomas comprise a heterogeneous group of mesenchymal neoplasms. They can be
grouped into 2 general categories, soft tissue sarcoma and primary bone sarcoma, which …

Over the last decade, a subset of familial adenomatous polyposis (FAP) patients with a
milder course of disease termed attenuated familial adenomatous polyposis (AFAP) has …

Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disorder, which
results from a germ line mutation in the APC (adenomatous polyposis coli) gene. FAP is …

Aggressive fibromatosis, also known as desmoid-type fibromatosis (DTF) or desmoid tumor,
is an uncommon locally invasive tumor. Because of its low incidence and variable behavior …