In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …

The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

Protein secretion is a common property of pathogenic microbes. Gram-negative bacterial
pathogens use at least 6 distinct extracellular protein secretion systems to export proteins …

The recently identified etiological agent of the severe acute respiratory syndrome (SARS)
belongs to Coronaviridae (CoV), a family of viruses replicating by a poorly understood …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

The heterotrimeric eukaryotic Replication protein A (RPA) is a master regulator of numerous
DNA metabolic processes. For a long time, it has been viewed as an inert protector of …

Remarkable progress has been made during the past ten years in elucidating the structure
of the bacteriophage T4 tail by a combination of three-dimensional image reconstruction …

Abstract Cdc13, Stn1 and Ten1 are essential yeast proteins that both protect chromosome
termini from unregulated resection and regulate telomere length. Cdc13, which localizes to …