The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical
region for recall and recognition memory. In a mechanistic proof-of-concept intervention over …

Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood
without replacement by bone marrow-derived circulating cells. In inflammation, stroke …

Plasticity is a basic process that underlies neural and cognitive functioning, unraveling thus
the former's pervasive role in development and learning. Plasticity processes operate in both …

Humans have long pondered the nature of their mind/brain and, particularly why its
capacities for reasoning, communication and abstract thought are far superior to other …

This narrative review examines literature pertaining to possible physiological explanations
for observed cognitive benefits stemming from improvements to cardiovascular fitness …

Adult hippocampal neurogenesis is a process involving the continuous generation of
newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested …

In recent years, both major depression and antidepressant therapy have been linked to adult
hippocampal neurogenesis. The hippocampus is not a homogeneous brain area, and a …