Stem cells in their natural microenvironment are exposed to biochemical and biophysical
cues emerging from the extracellular matrix (ECM) and neighboring cells. In particular …

In the development and differentiation of stem cells, mechanical forces associated with
filamentous actin (F-actin) play a crucial role. The present review aims to reveal the …

Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian
cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin …

Background The cytoskeleton is a key component of the system responsible for transmitting
mechanical cues from the cellular environment to the nucleus, where they trigger …

Here, we have reported that keratinocytes respond to the microflow‐induced shear stress
both at the collective and individual cell level. Using a microfluidic setup, we categorically …

Pancreatic islet transplantation is the fundamental treatment for insulin-dependent diabetes;
however, donor shortage is a major hurdle in its use as a standard treatment. Accordingly …

In the eukaryotic cell nucleus, cytoskeletal proteins are emerging as essential players in
nuclear function. In particular, actin regulates chromatin as part of ATP-dependent chromatin …

The intricate interplay between biochemical and physical cues dictates pluripotent stem cell
(PSC) differentiation to form various tissues. While biochemical modulation has been …

Background The challenge of expanding haematopoietic stem/progenitor cells (HSPCs) in
vitro has limited their clinical application. Human hair follicle mesenchymal stem cells …

Pluripotent stem cells (PSCs) are important for future regenerative medicine therapies.
However, in the production of PSCs and derivatives, the control of culture-induced …