Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …

Mitochondria are organelles of endosymbiotic origin, surrounded by two membranes. The
inner membrane forms invaginations called cristae that enhance its surface and are …

Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …

Mitophagy is essential to maintain mitochondrial function and prevent diseases. It activates
upon mitochondria depolarization, which causes PINK1 stabilization on the mitochondrial …

The elaborate membrane architecture of mitochondria is a prerequisite for efficient
respiration and ATP generation. The cristae membranes, invaginations of the inner …

We have analyzed the distribution of mitochondrial contact site and cristae organizing
system (MICOS) complex proteins and mitochondrial intermembrane space bridging …

Mitochondria possess two membranes of different architecture. The outer membrane
surrounds the organelle, whereas the inner membrane consists of two domains. The inner …

Simple Summary Mitochondria possess an outer and inner membrane. The part of the inner
membrane parallel to the outer membrane is termed the inner boundary membrane, while …

Hsp70s comprise a deeply conserved chaperone family that has a central role in
maintaining protein homeostasis. In humans, Hsp70 client specificity is provided by 49 …

The mitochondrial contact site and cristae junction (CJ) organizing system (MICOS)
dynamically regulate mitochondrial membrane architecture. Through systematic proteomic …