Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics

W Liu, A Puri, D Fu, L Chen, C Wang, M Kellis… - Clinical & Experimental …, 2024 - Springer
Cancer is a disease that undergoes selective pressure to evolve during its progression,
becoming increasingly heterogeneous. Tumoral heterogeneity can dictate therapeutic …

Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota

L Chen, YX Xu, YS Wang, YY Ren, XM Dong, P Wu… - Molecular Cancer, 2024 - Springer
Prostate cancer (PCa) is one of the most prevalent malignancies in males worldwide.
Increasing research attention has focused on the PCa microenvironment, which plays a …

[HTML][HTML] Artificial Intelligence for Prediction of Metastasis Risk and Survival

N Zahmatkesh, SS Babaei, SH Manesh, M Abbaspour… - Kindle, 2024 - preferpub.org
Artificial Intelligence (AI) has emerged as a transformative tool in predicting metastasis risk
and survival outcomes in cancer care. Traditional methods for assessing cancer progression …

Spatial proteomic profiling elucidates immune determinants of neoadjuvant chemo-immunotherapy in esophageal squamous cell carcinoma

C Wu, G Zhang, L Wang, J Hu, Z Ju, H Tao, Q Li, J Li… - Oncogene, 2024 - nature.com
Esophageal squamous cell carcinoma (ESCC) presents significant clinical and therapeutic
challenges due to its aggressive nature and generally poor prognosis. We initiated a Phase …

[HTML][HTML] Overexpression of FBP1 enhances dendritic cell activation and maturation by inhibiting glycolysis and promoting the secretion of IL33 in lung …

C Li, L Zhu, Y Yang, T Zhang, C Chen, Y Zhang… - … et Biophysica Acta (BBA …, 2025 - Elsevier
Abstract Fructose 1, 6-diphosphatase 1 (FBP1) is an enzyme involved in gluconeogenesis
and glycolysis inhibition. Dendritic cells (DCs) are antigen-presenting cells, and antigens …

[HTML][HTML] The current role of dendritic cells in the progression and treatment of colorectal cancer

Y Zhang, S Ji, G Miao, S Du, H Wang… - Cancer Biology & …, 2024 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related deaths worldwide. Dendritic cells (DCs) constitute a heterogeneous group of …

[PDF][PDF] Dendritic cells in head and neck cancer: from immune suppression to therapeutic activation through immunogenic cell death

L Guan, S Yang - Cancer Adv, 2024 - tmrjournals.com
Head and neck cancer (HNC) is a prevalent malignant tumor that is aggressive and
frequently resistant to treatment. Immunotherapy, a new approach for treating head and neck …