Staphylococcal osteomyelitis: disease progression, treatment challenges, and future directions

N Kavanagh, EJ Ryan, A Widaa, G Sexton… - Clinical microbiology …, 2018 - journals.asm.org
Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism
and leads to progressive bone destruction and loss. The most common causative species …

Intracellular targeting mechanisms by antimicrobial peptides

CF Le, CM Fang, SD Sekaran - Antimicrobial agents and …, 2017 - journals.asm.org
Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host
defenses against potential harmful encounters in their surroundings. AMPs are short …

Antibiofilm and antivirulence potential of silver nanoparticles against multidrug-resistant Acinetobacter baumannii

HF Hetta, IMS Al-Kadmy, SS Khazaal, S Abbas… - Scientific reports, 2021 - nature.com
We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections,
determine their resistance and virulence profile, and assess the impact of Silver …

Combating implant infections: shifting focus from bacteria to host

S Amin Yavari, SM Castenmiller… - Advanced …, 2020 - Wiley Online Library
The widespread use of biomaterials to support or replace body parts is increasingly
threatened by the risk of implant‐associated infections. In the quest for finding novel anti …

[HTML][HTML] Activity of specialized biomolecules against gram-positive and gram-negative bacteria

TD Tavares, JC Antunes, J Padrão, AI Ribeiro, A Zille… - Antibiotics, 2020 - mdpi.com
The increased resistance of bacteria against conventional pharmaceutical solutions, the
antibiotics, has raised serious health concerns. This has stimulated interest in the …

Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis

AR Zelmer, R Nelson, K Richter, GJ Atkins - Bone research, 2022 - nature.com
Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis

J Josse, F Velard, SC Gangloff - Frontiers in cellular and infection …, 2015 - frontiersin.org
Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for
bone extracellular matrix formation and resorption. This homeostasis is, in part, altered …

Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design

AF Brown, JM Leech, TR Rogers… - Frontiers in …, 2014 - frontiersin.org
In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior
nares of 20–80% of the human population. The relationship between host and microbe …

LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

X Wei, L Zhang, Y Yang, Y Hou, Y Xu, Z Wang, H Su… - Cell reports, 2022 - cell.com
Summary Cyclic 2′, 3′-GMP-AMP (cGAMP) binds to and activates stimulator of interferon
genes (STING), which then induces interferons to drive immune responses against tumors …

Biodegradable polymers and polymer composites with antibacterial properties

A Smola-Dmochowska, K Lewicka, A Macyk… - International journal of …, 2023 - mdpi.com
Antibiotic resistance is one of the greatest threats to global health and food security today. It
becomes increasingly difficult to treat infectious disorders because antibiotics, even the …