CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …

Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with
cigarette smoking, with patients often presenting with metastatic disease at the time of …

Pulmonary neuroendocrine tumors (NETs) are traditionally described as comprising a
spectrum of neoplasms, ranging from low grade typical carcinoids (TCs) via the intermediate …

Purpose KIT is a target for imatinib mesylate (Gleevec; Novartis Pharma, Basel,
Switzerland). Gastrointestinal stromal tumors (GISTs) express KIT and respond favorably to …

Small cell carcinoma of the prostate (SCPC) is morphologically similar to small cell
carcinoma of the lung (SCLC) and maybe misinterpreted as Gleason pattern 5b prostate …

Small cell lung cancer accounts for less than 20% of all lung cancer. The management of
this distinct tumor entity differs from the more common non-small cell lung cancer. Primary …

Purpose: The purpose of our study was to assess the objective response to imatinib
administered to patients with small cell lung cancer (SCLC). Experimental Design: Eligible …

Purpose: To evaluate the therapeutic and biological effects of CHIR-258, an orally
bioavailable, potent inhibitor of class III-V receptor tyrosine kinases, in colon cancer models …