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Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis
Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …
Biomaterials for articular cartilage tissue engineering: Learning from biology
Articular cartilage is commonly described as a tissue that is made of up to 80% water, is
devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the …
devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the …
Osteoarthritis as a disease of the cartilage pericellular matrix
Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …
articular cartilage as well as associated changes to the subchondral bone, synovium, and …
Cartilage-related collagens in osteoarthritis and rheumatoid arthritis: from pathogenesis to therapeutics
Z Ouyang, L Dong, F Yao, K Wang, Y Chen… - International Journal of …, 2023 - mdpi.com
Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …
connective tissues. In articular cartilage, collagens provide most of the biomechanical …
TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading
Mechanical loading of joints plays a critical role in maintaining the health and function of
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …
Biomechanical factors in osteoarthritis
Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …
[HTML][HTML] The structure and function of the pericellular matrix of articular cartilage
Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM)
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
The joints of mammals are lined with cartilage, comprised of individual chondrocytes
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …
Biomechanics of chondrocytes and chondrons in healthy conditions and osteoarthritis: A review of the mechanical characterisations at the microscale
Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …
biomedical engineering. From the molecular to the system level, mechanical stimuli are …
The ECM‐cell interaction of cartilage extracellular matrix on chondrocytes
Y Gao, S Liu, J Huang, W Guo, J Chen… - BioMed research …, 2014 - Wiley Online Library
Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen
(COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic …
(COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic …