[HTML][HTML] Sirtuin signaling in cellular senescence and aging
Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …
lifespan through the regulation of diverse cellular processes. Suppression of cellular …
Sirtuin activators and inhibitors: Promises, achievements, and challenges
H Dai, DA Sinclair, JL Ellis, C Steegborn - Pharmacology & therapeutics, 2018 - Elsevier
The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …
physiological functions, from energy metabolism to stress responses. The human Sirtuin …
Pyridinium salts: from synthesis to reactivity and applications
Structurally diverse pyridinium salts are quite familiar structures in many natural products
and bioactive pharmaceuticals. Over the centuries, these privileged scaffolds have played …
and bioactive pharmaceuticals. Over the centuries, these privileged scaffolds have played …
Sirtuin functions and modulation: from chemistry to the clinic
V Carafa, D Rotili, M Forgione, F Cuomo… - Clinical …, 2016 - Springer
Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic
pathways in prokaryotes and eukaryotes and are involved in many biological processes …
pathways in prokaryotes and eukaryotes and are involved in many biological processes …
Mitochondrial dysfunction in the pathophysiology of renal diseases
R Che, Y Yuan, S Huang… - American Journal of …, 2014 - journals.physiology.org
Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …
Seven sirtuins for seven deadly diseases ofaging
BJ Morris - Free Radical Biology and Medicine, 2013 - Elsevier
Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …
extensive review describes the numerous intracellular actions of the seven mammalian …
Pharmacological approaches to restore mitochondrial function
Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but
also implicated in age-related diseases, including those that affect the metabolic and …
also implicated in age-related diseases, including those that affect the metabolic and …
Sirtuin activators and inhibitors
JM Villalba, FJ Alcaín - Biofactors, 2012 - Wiley Online Library
Abstract Sirtuins 1‐7 (SIRT1‐7) belong to the third class of deacetylase enzymes, which are
dependent on NAD+ for activity. Sirtuins activity is linked to gene repression, metabolic …
dependent on NAD+ for activity. Sirtuins activity is linked to gene repression, metabolic …
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
M Gertz, F Fischer, GTT Nguyen… - Proceedings of the …, 2013 - National Acad Sciences
Sirtuins are protein deacetylases regulating metabolism and stress responses. The seven
human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are …
human Sirtuins (Sirt1–7) are attractive drug targets, but Sirtuin inhibition mechanisms are …
Are sirtuins viable targets for improving healthspan and lifespan?
Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of develo** many diseases increases exponentially with old age …
medicine, the risk of develo** many diseases increases exponentially with old age …