Normal and defective pathways in biogenesis and maintenance of the insulin storage pool
Both basal and glucose-stimulated insulin release occur primarily by insulin secretory
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …
Glucose-regulated protein 94 (GRP94): a novel regulator of insulin-like growth factor production
Mammals have two insulin-like growth factors (IGF) that are key mediators of somatic growth,
tissue differentiation, and cellular responses to stress. Thus, the mechanisms that regulate …
tissue differentiation, and cellular responses to stress. Thus, the mechanisms that regulate …
[HTML][HTML] The role of the immunoproteasome in cardiovascular disease
Y Nie, Z Ma, B Zhang, M Sun, D Zhang, HH Li… - Pharmacological …, 2024 - Elsevier
The ubiquitinsingle bondproteasome system (UPS) is the main mechanism responsible for
the intracellular degradation of misfolded or damaged proteins. Under inflammatory …
the intracellular degradation of misfolded or damaged proteins. Under inflammatory …
Sphingolipids in type 1 diabetes: focus on beta-cells
E Gurgul-Convey - Cells, 2020 - mdpi.com
Type 1 diabetes (T1DM) is a chronic autoimmune disease, with a strong genetic
background, leading to a gradual loss of pancreatic beta-cells, which secrete insulin and …
background, leading to a gradual loss of pancreatic beta-cells, which secrete insulin and …
Insight into the nucleotide based modulation of the Grp94 molecular chaperone using multiscale dynamics
Grp94, an ER-localized molecular chaperone, is required for the folding and activation of
many membrane and secretory proteins. Client activation by Grp94 is mediated by …
many membrane and secretory proteins. Client activation by Grp94 is mediated by …
Defective proinsulin handling modulates the MHC I bound peptidome and activates the inflammasome in β-cells
How immune tolerance is lost to pancreatic β-cell peptides triggering autoimmune type 1
diabetes is enigmatic. We have shown that loss of the proinsulin chaperone glucose …
diabetes is enigmatic. We have shown that loss of the proinsulin chaperone glucose …
[PDF][PDF] Lactic acid bacteria fermented foods: Impact on immune system and consequences over type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease affecting millions worldwide.
Recent studies suggest that dietary interventions may improve glycemic control and lower …
Recent studies suggest that dietary interventions may improve glycemic control and lower …
A cell-based Platform for the investigation of immunoproteasome subunit β5i expression and biology of β5i-containing proteasomes
The degradation of most intracellular proteins is a dynamic and tightly regulated process
performed by proteasomes. To date, different forms of proteasomes have been identified …
performed by proteasomes. To date, different forms of proteasomes have been identified …
Insulin Secretory Granule biogenesis and VPS41
Y An - 2023 - ses.library.usyd.edu.au
The pancreatic beta cells are not only the fundamental source of insulin production but also
the predominant regulator of its storage and release upon appropriate stimuli to maintain …
the predominant regulator of its storage and release upon appropriate stimuli to maintain …
Exploring mechanisms of insulin secretion regulators using C. elegans
A Podraza-Farhanieh - 2022 - gupea.ub.gu.se
Diabetes mellitus is a group of disorders characterized by disrupted glucose homeostasis.
Diabetes is one of the most dangerous diseases worldwide since it affects currently more …
Diabetes is one of the most dangerous diseases worldwide since it affects currently more …