CD44: a multifunctional mediator of cancer progression
CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …
[HTML][HTML] Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
D Chen, X Zhang, Z Li, B Zhu - Theranostics, 2021 - ncbi.nlm.nih.gov
Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …
Pancreatic tumor microenvironment factor promotes cancer stemness via SPP1–CD44 axis
Background & Aims Tumor-microenvironment factors and cancer stem cells (CSCs) play a
critical role in the aggressiveness of pancreatic cancer (PC). However, the degree to which …
critical role in the aggressiveness of pancreatic cancer (PC). However, the degree to which …
Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling
Ovarian cancer is the leading cause of gynecological malignancy–related deaths, due to its
widespread intraperitoneal metastases and acquired chemoresistance. Mesothelial cells are …
widespread intraperitoneal metastases and acquired chemoresistance. Mesothelial cells are …
[HTML][HTML] Different responses to neoadjuvant chemotherapy in urothelial carcinoma molecular subtypes
Background For muscle-invasive bladder cancer (MIBC), no tissue biomarkers are available
for clinical use to predict response to neoadjuvant chemotherapy. Objective To investigate …
for clinical use to predict response to neoadjuvant chemotherapy. Objective To investigate …
Osteopontin: a key regulator of tumor progression and immunomodulation
Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …
[HTML][HTML] Cancer-associated fibroblast-derived IL-6 promotes head and neck cancer progression via the osteopontin-NF-kappa B signaling pathway
X Qin, M Yan, X Wang, Q Xu, X Wang, X Zhu, J Shi… - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Osteopontin (OPN), a chemokine-like protein, plays a crucial role in the proliferation
and metastasis of various cancers. However, how tumor stroma modulates the expression of …
and metastasis of various cancers. However, how tumor stroma modulates the expression of …
Tumor-associated macrophages in bladder cancer: biological role, impact on therapeutic response and perspectives for immunotherapy
MM Leblond, H Zdimerova, E Desponds, G Verdeil - Cancers, 2021 - mdpi.com
Simple Summary Tumor-associated macrophages (TAMs) play major roles in solid tumor
development. They can have both anti-tumor and pro-tumor properties depending on their …
development. They can have both anti-tumor and pro-tumor properties depending on their …
Osteopontin in cancer: mechanisms and therapeutic targets
Y Kariya, Y Kariya - International Journal of Translational Medicine, 2022 - mdpi.com
Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …
cause of death worldwide. Expression of the tumor microenvironment component …
Adipocyte p62/SQSTM1 suppresses tumorigenesis through opposite regulations of metabolism in adipose tissue and tumor
Obesity is a leading risk factor for cancer. However, understanding the crosstalk between
adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in …
adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in …