The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes …

How vascular endothelial growth factor (VEGF) induces vascular permeability, its first
described function, remains poorly understood. Here, we provide evidence of a novel …

Physiological effects of β adrenergic receptor (β2AR) stimulation have been classically
shown to result from G s-dependent adenylyl cyclase activation. Here we demonstrate a …

The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …

Abstract β-Arrestins critically regulate G-protein-coupled receptor (GPCR) signalling, not
only 'arresting'the G protein signal but also modulating endocytosis and initiating a discrete …

To ensure that extracellular stimuli are translated into intracellular signals of appropriate
magnitude and specificity, most signaling cascades are tightly regulated. One of the major …

Stimulation of cell-surface seven-transmembrane receptors (7TMRs) elicits biological
responses to a wide range of extracellular signals, including many hormones. Classically …

The endocytic pathway tightly controls the activity of G protein–coupled receptors (GPCRs).
Ligand-induced endocytosis can drive receptors into divergent lysosomal and recycling …

Cells rely on the correct sorting of endocytic ligands and receptors for proper function. Early
endosomes have been considered as the initial sorting station where cargos for degradation …