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Disrupted neuronal trafficking in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease
caused by degeneration of motor neurons in the brain and spinal cord leading to muscle …
caused by degeneration of motor neurons in the brain and spinal cord leading to muscle …
Emerging views of OPTN (optineurin) function in the autophagic process associated with disease
Macroautophagy/autophagy is a highly conserved process in eukaryotic cells. It plays a
critical role in cellular homeostasis by delivering cytoplasmic cargos to lysosomes for …
critical role in cellular homeostasis by delivering cytoplasmic cargos to lysosomes for …
Major review: Molecular genetics of primary open-angle glaucoma
Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …
glaucoma (POAG), the most common type, is a complex inherited disorder that is …
Nitrogen and phosphorus co-doped graphene quantum dots: synthesis from adenosine triphosphate, optical properties, and cellular imaging
Graphene quantum dots (GQDs) are emerging zero-dimensional materials promising a wide
spectrum of applications, particularly, as superior fluorescent reporters for bio-imaging and …
spectrum of applications, particularly, as superior fluorescent reporters for bio-imaging and …
The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology
SF Janssen, TGMF Gorgels, WD Ramdas… - Progress in retinal and …, 2013 - Elsevier
Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …
triggered by both environmental and genetic risk factors. Several ocular tissues, including …
Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative …
OPTN (optineurin) is an autophagy receptor and mutations in the OPTN gene result in
familial glaucoma (E50K) and amyotrophic lateral sclerosis (ALS)(E478G). However, the …
familial glaucoma (E50K) and amyotrophic lateral sclerosis (ALS)(E478G). However, the …
Optineurin: a coordinator of membrane-associated cargo trafficking and autophagy
Optineurin is a multifunctional adaptor protein intimately involved in various vesicular
trafficking pathways. Through interactions with an array of proteins, such as myosin VI …
trafficking pathways. Through interactions with an array of proteins, such as myosin VI …
Dysfunction of optineurin in amyotrophic lateral sclerosis and glaucoma
Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal
dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of …
dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of …
Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma
Both exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) have been
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …
Significance of optineurin mutations in glaucoma and other diseases
Y Minegishi, M Nakayama, D Iejima, K Kawase… - Progress in retinal and …, 2016 - Elsevier
Glaucoma is one of the leading causes of bilateral blindness, affecting nearly 57 million
people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells …
people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells …