Schizophrenia is frequently a chronic and disabling disorder, characterized by
heterogeneous positive and negative symptom constellations. The objective of this review …

Abstract Changes over 50 years of research on antipsychotics in schizophrenia have
occurred. A scientometric synthesis of such changes over time and a measure of …

Schizophrenia is a debilitating mental illness which involves three groups of symptoms, ie,
positive, negative and cognitive, and has major public health implications. According to …

Importance It has remained unclear whether there are clinically meaningful differences
between antipsychotic treatments with regard to preventing relapse of schizophrenia, owing …

A recent increase in the literature regarding the evidence base for clozapine has made it
increasingly difficult for clinicians to judge “best evidence” for clozapine use. As such, we …

People with severe mental illness have a considerably shorter lifespan than the general
population. This excess mortality is mainly due to physical illness. Next to mental illness …

Objectives Existing treatments for schizophrenia can improve positive symptoms, but it is
unclear if they have any impact on negative symptoms. This meta-analysis was conducted to …

Objective: The present guidelines address the pharmacotherapy of schizophrenia in adults
across different stages, phases, and symptom domains. Method: Guidelines were developed …

Objective: The dose-response relationships of antipsychotic drugs for schizophrenia are not
well defined, but such information would be important for decision making by clinicians. The …

Background Clinical research affecting how doctors practice medicine is increasingly
sponsored by companies that make drugs and medical devices. Previous systematic …