Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

J Hur, MD Stockbridge, AS Fox, AJ Shackman - Progress in brain research, 2019 - Elsevier
When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge
early in development, are common and challenging to treat, yet the underlying mechanisms …

Genetic variants in major depressive disorder: from pathophysiology to therapy

X Gonda, P Petschner, N Eszlari, D Baksa… - Pharmacology & …, 2019 - Elsevier
In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

Reproducible genetic risk loci for anxiety: results from∼ 200,000 participants in the Million Veteran Program

DF Levey, J Gelernter, R Polimanti… - American Journal of …, 2020 - psychiatryonline.org
Objective: Anxiety disorders are common and often disabling. The goal of this study was to
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …

The genetics of the mood disorder spectrum: genome-wide association analyses of more than 185,000 cases and 439,000 controls

JRI Coleman, HA Gaspar, J Bryois, EM Byrne… - Biological …, 2020 - Elsevier
Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe …

Network analysis of comorbid depression and anxiety and their associations with quality of life among clinicians in public hospitals during the late stage of the COVID …

Y **, S Sha, T Tian, Q Wang, S Liang, Z Wang… - Journal of Affective …, 2022 - Elsevier
Background Mental health problems are common among clinicians working in public
hospitals even in the late stage of the COVID-19 pandemic. Network analysis is a novel …

Genomics of body fat percentage may contribute to sex bias in anorexia nervosa

C Hübel, HA Gaspar, JRI Coleman… - American Journal of …, 2019 - Wiley Online Library
Anorexia nervosa (AN) occurs nine times more often in females than in males. Although
environmental factors likely play a role, the reasons for this imbalanced sex ratio remain …

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex-and age-dependent

C Hübel, HA Gaspar, JRI Coleman… - Nature …, 2019 - nature.com
Body composition is often altered in psychiatric disorders. Using genome-wide common
genetic variation data, we calculate sex-specific genetic correlations amongst body fat%, fat …

[HTML][HTML] The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety

MR Davies, G Kalsi, C Armour, IR Jones… - … Research and Therapy, 2019 - Elsevier
Background Anxiety and depression are common, debilitating and costly. These disorders
are influenced by multiple risk factors, from genes to psychological vulnerabilities and …

Extracting stability increases the SNP heritability of emotional problems in young people

R Cheesman… - Translational …, 2018 - nature.com
Twin studies have shown that emotional problems (anxiety and depression) in childhood
and adolescence are moderately heritable (~ 20–50%). In contrast, DNA-based 'SNP …

The genetic and environmental hierarchical structure of anxiety and depression in the UK Biobank

G Morneau‐Vaillancourt, JRI Coleman… - Depression and …, 2020 - Wiley Online Library
Background Anxiety and depressive disorders can be classified under a bidimensional
model, where depression and generalized anxiety disorder are represented by distress and …