2-Oxoglutarate-dependent dioxygenases in cancer
JA Losman, P Koivunen, WG Kaelin Jr - Nature Reviews Cancer, 2020 - nature.com
Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
Tumor hypoxia: From basic knowledge to therapeutic implications
Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …
[HTML][HTML] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer
Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1,
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune
checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could …
checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could …
CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer
Summary Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene
transcription. However, little is known about its impact on genomic instability and cancer …
transcription. However, little is known about its impact on genomic instability and cancer …
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma,
leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia …
leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia …
[HTML][HTML] SCLC: epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection
We review research regarding the epidemiology, risk factors, genetic susceptibility,
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in small cell lung cancer
Activating innate immunity in cancer cells through cytoplasmic nucleic acid sensing
pathways, a phenomenon known as “viral mimicry,” has emerged as an effective strategy to …
pathways, a phenomenon known as “viral mimicry,” has emerged as an effective strategy to …
The emerging role of KDM5A in human cancer
GJ Yang, MH Zhu, XJ Lu, YJ Liu, JF Lu… - Journal of hematology & …, 2021 - Springer
Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …
dysregulation affects a wide array of nuclear activities including the maintenance of genome …