Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

The rationale for replacing the old binary of structure–function with the trinity of structure,
disorder, and function has gained considerable ground in recent years. A continuum model …

The burgeoning comprehension of protein phase separation (PS) has ushered in a wealth of
bioinformatics tools for the prediction of phase-separating proteins (PSPs). These tools often …

Incorporating passive heating structures into personal thermal management technologies
could effectively mitigate the escalating energy crisis. However, current passive heating …

The rules of how amino acids dictate the physical properties of biomolecular condensates
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …

The deposition of α-synuclein (α-Syn) in Lewy bodies serves as a prominent pathological
hallmark of Parkinson's disease (PD). Recent research has revealed that α-Syn can undergo …

The accumulation of abnormal protein deposits known as amyloid-β (Aβ) plaques
contributes to the development and progression of Alzheimer's disease. Aggregated Aβ …

Phase separation is thought to be one possible mechanism governing the selective cellular
enrichment of biomolecular constituents for processes such as transcriptional activation …

Liquid–Liquid phase separation (LLPS) of p53 to form liquid condensates has been
implicated in cellular functions and dysfunctions. The p53 condensates may serve as …

The presence of Ca2+ ions is known to facilitate the activity of trypsin-like serine proteases
via structural stabilization against thermal denaturation and autolysis. Herein, we report a …