UK Biobank is a large-scale prospective study with deep phenoty** and genomic data. Its
open-access policy allows researchers worldwide, from academia or industry, to perform …

Telomere attrition is a proposed hallmark of aging. To evaluate the association of telomere
length (TL) with chronological age across the human lifespan, we conducted a systematic …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

Circulating plasma proteins play key roles in human health and can potentially be used to
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …

The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …

Telomeres protect chromosome ends from damage and their length is linked with human
disease and aging. We developed a joint telomere length metric, combining quantitative …

Alcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We
performed the largest observational study to date (in n= 245,354 UK Biobank participants) …

Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative
and quantitative features of biological aging and might, therefore, offer useful information for …

Background Telomere length is associated with risk of several age-related diseases and
cancers. We aimed to investigate the extent to which telomere length might be modifiable …