The control of male fertility by spermatozoan ion channels

PV Lishko, Y Kirichok, D Ren, B Navarro… - Annual review of …, 2012 - annualreviews.org
Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in
the female reproductive tract and by triggering key sperm physiological responses required …

Sperm migration, selection, survival, and fertilizing ability in the mammalian oviduct

C Mahé, AM Zlotkowska, K Reynaud… - Biology of …, 2021 - academic.oup.com
In vitro fertilization (IVF) gives rise to embryos in a number of mammalian species and is
currently widely used for assisted reproduction in humans and for genetic purposes in cattle …

Progesterone activates the principal Ca2+ channel of human sperm

PV Lishko, IL Botchkina, Y Kirichok - Nature, 2011 - nature.com
Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent
stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them …

Mechanisms of sperm chemotaxis

UB Kaupp, ND Kashikar, I Weyand - Annu. Rev. Physiol., 2008 - annualreviews.org
Sperm are attracted by chemical factors that are released by the egg—a process called
chemotaxis. Most of our knowledge on sperm chemotaxis originates from the study of marine …

Sperm processing for advanced reproductive technologies: Where are we today?

KL Rappa, HF Rodriguez, GC Hakkarainen… - Biotechnology …, 2016 - Elsevier
Assisted reproductive technologies (ARTs) utilize sperm sorting methods to select viable
sperm from the semen samples. Conventional sperm sorting techniques in current use are …

[Ca2+]i signalling in sperm — making the most of what you've got

S Publicover, CV Harper, C Barratt - Nature cell biology, 2007 - nature.com
Thanks to a worrying decrease in male fertility, understanding how sperm'work'is a matter
both of interest and great importance. Sperm of all animals detect various environmental …

Simulating nature in sperm selection for assisted reproduction

ETY Leung, CL Lee, X Tian, KKW Lam, RHW Li… - Nature Reviews …, 2022 - nature.com
Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000
sperm out of millions in an ejaculate reach the fallopian tube and thus have a chance of …

Bend propagation in the flagella of migrating human sperm, and its modulation by viscosity

DJ Smith, EA Gaffney, H Gadêlha… - Cell motility and the …, 2009 - Wiley Online Library
A pre‐requisite for sexual reproduction is successful unification of the male and female
gametes; in externally‐fertilising echinoderms the male gamete is brought into close …

Human sperm ion channel (dys) function: implications for fertilization

SG Brown, SJ Publicover, CLR Barratt… - Human reproduction …, 2019 - academic.oup.com
BACKGROUND Intensive research on sperm ion channels has identified members of
several ion channel families in both mouse and human sperm. Gene knock-out studies have …

Ca2+ Signaling Tools Acquired from Prostasomes Are Required for Progesterone-Induced Sperm Motility

KH Park, BJ Kim, J Kang, TS Nam, JM Lim, HT Kim… - Science …, 2011 - science.org
Progesterone-induced calcium ion (Ca2+) signals in the neck region of sperm play a pivotal
role in promoting sperm motility. Here, we show that a long-lasting Ca2+ signal required for …