Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …

Platelets have been hypothesized to promote certain neoplastic malignancies; however,
antiplatelet drugs are still not part of routine pharmacological cancer prevention and …

Purpose To develop guideline recommendations for the use of anticoagulation in the
prevention and treatment of venous thromboembolism (VTE) in patients with cancer …

Independent studies indicate that expression of sialylated fucosylated mucins by human
carcinomas portends a poor prognosis because of enhanced metastatic spread of tumor …

Deep venous thrombosis (DVT) and pulmonary embolism (PE) are well recognized
complications of cancer. However, our current knowledge of this association is derived from …

Purpose Studies in cancer patients with venous thromboembolism suggested that low
molecular weight heparin may prolong survival. In a double-blind study, we evaluated the …

In addition to its primary role in hemostasis and blood coagulation, thrombin is a potent
mitogen capable of inducing cellular functions. Therefore, it should come as no surprise that …

Purpose Experimental studies and indirect clinical evidence suggest that low molecular
weight heparins may have antineoplastic effects. We investigated the influence of a low …

P-selectin facilitates human carcinoma metastasis in immunodeficient mice by mediating
early interactions of platelets with bloodborne tumor cells via their cell surface mucins, and …