Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Abstract The Yorkie homologues YAP (Yes-associated protein) and TAZ (transcriptional
coactivator with PDZ-binding motif, also known as WWTR1), effectors of the Hippo pathway …

Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where
blood flow pattern is disturbed rather than being laminar, and wall shear stress has an …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Located in the innermost layer of the vasculature and directly interacting with blood flow,
endothelium integrates various biochemical and biomechanical signals to maintain barrier …

Shear stress is essential for normal physiology and malignancy. Common physiological
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …

Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …

The vascular system is critical for developmental growth, tissue homeostasis and repair but
also for tumor development. Bone morphogenetic protein (BMP) signaling has recently …