Single-cell RNA sequencing is the reference technology to characterize the composition of
the tumor microenvironment and to study tumor heterogeneity at high resolution. Here we …

Background: Somatic copy number aberrations (CNAs) are common acquired changes in
cancer cells having an important role in the progression of colon cancer (colorectal cancer …

Identifying driver genes in cancer remains a crucial bottleneck in therapeutic development
and basic understanding of the disease. We developed Helios, an algorithm that integrates …

Background Lung cancer is the leading cause of the largest number of deaths worldwide
and lung adenocarcinoma is the most common form of lung cancer. In order to understand …

Endometrial cancer (EC) is now the most prevalent gynaecological malignancy in the
Western world. Black or African American women (BoAA) have double the mortality of …

Copy number alterations (CNAs) comprise deletions or amplifications of fragments of
genomic material that are particularly common in cancer and play a major contribution in its …

Abstract Copy Number Alterations (CNAs) represent the most common genetic alterations
identified in ovarian cancer cells, being responsible for the extensive genomic instability …

Analyzing copy number variations (CNVs) from next-generation sequencing (NGS) data has
become a common approach to detect disease susceptibility genes. The main challenge is …

A common strategy to discovering cancer associated copy number aberrations (CNAs) from
a cohort of cancer samples is to detect recurrent CNAs (RCNAs). Although the previous …

Motivation: Somatic copy number aberrations (SCNAs) are frequent in cancer genomes, but
many of these are random, passenger events. A common strategy to distinguish functional …