The establishing of the first cancer models created a new perspective on the identification
and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft …

Organoids are in vitro–cultured three-dimensional structures that recapitulate key aspects of
in vivo organs. They can be established from pluripotent stem cells and from adult stem …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Purpose: Non–small cell lung cancer (NSCLC) is the most common cause of cancer-related
deaths worldwide. There is an unmet need to develop novel clinically relevant models of …

Progress in oncology drug development has been hampered by a lack of preclinical models
that reliably predict clinical activity of novel compounds in cancer patients. In an effort to …

Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate
the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX …

Preclinical models of cancer are essential for a basic understanding of cancer biology and
its translation into efficient treatment options for affected patients. Cancer cell lines and …

Over the last few decades, study of cancer in mouse models has gained popularity.
Sophisticated genetic manipulation technologies and commercialization of these murine …

The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …

Three-dimensional cultured organoids have become a powerful in vitro research tool that
preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be …