Metabolomic epidemiology offers insights into disease aetiology
Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …
metabolites and health-related traits. This emerging and rapidly growing field has improved …
Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank
Blood lipids and metabolites are markers of current health and future disease risk. Here, we
describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 …
describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 …
Understanding genetic variants in context
Over the last three decades, human genetics has gone from dissecting high-penetrance
Mendelian diseases to discovering the vast and complex genetic etiology of common human …
Mendelian diseases to discovering the vast and complex genetic etiology of common human …
Genome-wide characterization of circulating metabolic biomarkers
Genome-wide association analyses using high-throughput metabolomics platforms have led
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …
Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank
Genome-wide association studies (GWASs) have established the contribution of common
and low-frequency variants to metabolic blood measurements in the UK Biobank (UKB). To …
and low-frequency variants to metabolic blood measurements in the UK Biobank (UKB). To …
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex
traits vary widely, including in terms of the numbers, effect sizes, and allele frequencies of …
traits vary widely, including in terms of the numbers, effect sizes, and allele frequencies of …
Exploiting the mediating role of the metabolome to unravel transcript-to-phenotype associations
Despite the success of genome-wide association studies (GWASs) in identifying genetic
variants associated with complex traits, understanding the mechanisms behind these …
variants associated with complex traits, understanding the mechanisms behind these …
Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases
MJ Taeubert, TB Kuipers, J Zhou, C Li, S Wang… - BMC medicine, 2024 - Springer
Background Exposure to famine in the prenatal period is associated with an increased risk
of metabolic disease, including obesity and type 2 diabetes. We employed nuclear magnetic …
of metabolic disease, including obesity and type 2 diabetes. We employed nuclear magnetic …
Interplay between plasma glycine and branched-chain amino acids contributes to the development of hypertension and coronary heart disease
M Dziedzic, E Józefczuk, TJ Guzik, M Siedlinski - Hypertension, 2024 - Am Heart Assoc
BACKGROUND: Higher levels of plasma glycine are linked to a reduced risk, while
increased levels of total branched-chain amino acids (tBCAAs) are associated with a higher …
increased levels of total branched-chain amino acids (tBCAAs) are associated with a higher …
Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes
RDM Varkevisser, A Cecil, C Prehn, D Mul… - Scientific Reports, 2024 - nature.com
This study investigates impaired awareness of hypoglycaemia (IAH), a complication of
insulin therapy affecting 20–40% of individuals with type 1 diabetes. The exact …
insulin therapy affecting 20–40% of individuals with type 1 diabetes. The exact …