Myofibrillogenesis in striated muscles is a highly complex process that depends on the
coordinated assembly and integration of a large number of contractile, cytoskeletal, and …

In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …

Obscurin, a giant modular muscle protein implicated in G-protein and protein-kinase
signalling, can localize to both sarcomeric Z-disks and M-bands. Interaction of obscurin with …

Background The force generating mechanism of muscle is evolutionarily ancient; the
fundamental structural and functional components of the sarcomere are common to motile …

The nematode Caenorhabditis elegans has become established as a major experimental
organism with applications to many biomedical research areas. The body wall muscle cells …

UNC-89 is a giant sarcomeric M-line protein required for sarcomere organization and
optimal muscle function. UNC-89 contains two protein kinase domains, PK1 and PK2 …

Discovered about a decade ago, obscurin (∼ 720 kDa) is a member of a family of giant
proteins expressed in striated muscle that are essential for normal muscle function. Much of …

The obscurin family of polypeptides is essential for normal striated muscle function and
contributes to the pathogenesis of fatal diseases, including cardiomyopathies and cancers …

The nematode Caenorhabditis elegans uses striated muscle in its body wall for locomotion.
The myofilament lattice is organized such that all the thin filament attachment structures …

Calcium, a ubiquitous intracellular signaling molecule, controls a diverse array of cellular
processes. Consequently, cells have developed strategies to modulate the shape of calcium …