Ovarian cancer is mostly diagnosed at an advanced stage due to the absence of effective
screening methods and specific symptoms. Repeated chemotherapy resistance and …

Chloroquine is a common antimalarial drug and is listed in the World Health Organization
Standard List of Essential Medicines because of its safety, low cost and ease of use. Besides …

Abstract PFKFB3 (6-phosphofructo-2-kinase) is the rate-limiting enzyme of glycolysis and is
overexpressed in several human cancers that are associated with poor prognosis. High …

Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as
DC661 can produce cell death, but the mechanism for this is not completely understood …

Colorectal cancer (CRC) is one of the most frequent malignancies worldwide and remains
one of the leading causes of cancer-related deaths in the USA. The high degree of morbidity …

Lysosomes are acidic organelles that mediate the degradation and recycling of cellular
waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization …

Accumulating evidence indicates that the anticancer activity of acridine derivatives is
mediated through the regulation of anti-apoptotic and pro-apoptotic BCL2 protein …

Carbon black (CB), a component of environmental particulate pollution derived from carbon
sources, poses a significant threat to human health, particularly in the context of lung-related …

Cancer is one of the main causes of death globally. Radiotherapy/Radiation therapy (RT) is
one of the most common and effective cancer treatments. RT utilizes high-energy radiation …

A complex link exists between HIV-1 and autophagy, and discordant results have been
reported in different in vitro models regarding the way HIV and autophagy modulate each …