Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology
LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - Elsevier
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
Multifunctional intracellular matrix metalloproteinases: implications in disease
Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first
discovered as proteases, which target and cleave extracellular proteins. During the past 20 …
discovered as proteases, which target and cleave extracellular proteins. During the past 20 …
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound
Deep brain stimulation via implanted electrodes can alleviate neuronal disorders. However,
its applicability is constrained by side effects resulting from the insertion of electrodes into …
its applicability is constrained by side effects resulting from the insertion of electrodes into …
Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances
H Huang - Sensors, 2018 - mdpi.com
As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a
significant protease which plays vital roles in many biological processes. MMP-9 can cleave …
significant protease which plays vital roles in many biological processes. MMP-9 can cleave …
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
C Yang, KE Hawkins, S Doré… - American Journal of …, 2019 - journals.physiology.org
As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …
Pathogenic mechanisms following ischemic stroke
Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
[HTML][HTML] Functions and dysfunctions of nitric oxide in brain
P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …
flow and also has important roles in intracellular signaling in neurons from the regulation of …
The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
The basics of thiols and cysteines in redox biology and chemistry
LB Poole - Free Radical Biology and Medicine, 2015 - Elsevier
Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …
Is there new hope for therapeutic matrix metalloproteinase inhibition?
RE Vandenbroucke, C Libert - Nature reviews Drug discovery, 2014 - nature.com
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …