The bioavailability of drugs—the current state of knowledge

M Stielow, A Witczyńska, N Kubryń, Ł Fijałkowski… - Molecules, 2023 - mdpi.com
Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug
therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in …

[HTML][HTML] Efficient synthesis of new azo-sulfonamide derivatives and investigation of their molecular docking and cytotoxicity results

NO Mahmoodi, A Ahmadi, HY Nyaki… - Arabian Journal of …, 2022 - Elsevier
The present study focused on the synthesis, introduction and investigation of the biological
effects of sulfonamide-derived products as new azo-sulfonamides (samples 1–6). In this …

Integrating Nanotechnological Advancements of Disease-Modifying Anti-Rheumatic Drugs into Rheumatoid Arthritis Management

S Singh, N Tiwary, N Sharma, T Behl, A Antil… - Pharmaceuticals, 2024 - mdpi.com
Disease-modifying anti-rheumatic drugs (DMARDs) is a class of anti-rheumatic medicines
that are frequently prescribed to patients suffering from rheumatoid arthritis (RA) …

A comparison between optimized PLGA and CS-Alg-PLGA microspheres for long-lasting release of glatiramer acetate

M Hajian, V Erfani-Moghadam, MS Arabi… - Journal of Drug Delivery …, 2023 - Elsevier
Abstract Glatiramer acetate (GA, Copaxone, COP, Copolymer-1) is one of the most
prescribed drugs to treat relapsing-remitting multiple sclerosis (RRMS). Herein, the formula …

Synergistic cytotoxicity of olive leaf extract-loaded lipid nanocarriers combined with Newcastle disease virus against cervical cancer cells

A Golalipour, A Mohammadi, S Hosseinzadeh… - Plos one, 2024 - journals.plos.org
Despite recent medical progress, cervical cancer remains a major global health concern for
women. Current standard treatments have limitations such as non-specific toxicity that …

[HTML][HTML] Formulation of Glibenclamide proniosomes for oral administration: Pharmaceutical and pharmacodynamics evaluation

D Alshora, M Ibrahim, N Alanazi, M Alowyid… - Saudi Pharmaceutical …, 2023 - Elsevier
Glibenclamide (GB), oral antidiabetic sulfonylurea, is used in the management of diabetes
mellitus type II. It suffers from low bioavailability due to low water solubility. This work aimed …

Quality by Design (QbD) enabled and Box-Behnken design assisted approach for formulation of tranexamic acid loaded stratum corneum lipid liposomes

P Verma, KS Yadav - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Tranexamic acid, a highly hydrophilic drug, is used for treatment of hyperpigmentation but
topical delivery of drug is limited by poor permeation across lipidic stratum corneum …

Theoretical and experimental studies on sulfasalazine interactions with poly (lactic acid): Impact of hydrogen bonding and charge transfer interactions on molecular …

AN Safa, A Sheibani, MT Baei, SZ Sayyed-Alangi… - Heliyon, 2024 - cell.com
The interaction between sulfasalazine (SSZ) through different functional groups and poly
(lactic acid)(PLA) in the chloroform phase was investigated in this study using density …

Experimental and theoretical studies on the interaction of finasteride with chitosan-based nanoniosomes

M Pishnamazi, SM Dhiaa, R Emadi… - Journal of Molecular …, 2024 - Elsevier
This research is aimed to develop a novel finasteride (FIN) release system based on
chitosan-based nanoniosomes (CS-Nio) by thin-film hydration method. The particle size …

Glutathione-modified hyaluronic acid nanoparticles for the targeted delivery of sulfasalazine to neuroblastoma

M Kasprzyk, A Hinz, M Bzowska, D Lachowicz… - European Polymer …, 2024 - Elsevier
A new nanoparticulate system based on hyaluronic acid for targeted delivery of
sulfasalazine (SSA) to neuroblastoma was synthetized and characterized. The SSA …