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[HTML][HTML] Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?
Vascular cognitive impairment (VCI) describes neurodegenerative disorders characterized
by a vascular component. Pathologically, it involves decreased cerebral blood flow (CBF) …
by a vascular component. Pathologically, it involves decreased cerebral blood flow (CBF) …
Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer's disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway …
Dysregulation of protein homeostasis, proteostasis, is a distinctive hallmark of many
neurodegenerative disorders and aging. Deleteriously, the accumulation of aberrant …
neurodegenerative disorders and aging. Deleteriously, the accumulation of aberrant …
The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report
Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading
enzymes or stimulating cGMP production are approved for the treatment of various diseases …
enzymes or stimulating cGMP production are approved for the treatment of various diseases …
BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation
Mutations of large conductance Ca2+-and voltage-activated K+ channels (BK) are
associated with cognitive impairment. Here we report that CA1 pyramidal neuron-specific …
associated with cognitive impairment. Here we report that CA1 pyramidal neuron-specific …
Vericiguat preserved cardiac function and mitochondrial quality in a rat model of mitral regurgitation
P Jungtanasomboon, S Nussaro, H Winwan… - Life Sciences, 2023 - Elsevier
Aims New drugs for heart failure (HF) that target restoring the impaired NO-sGC-cGMP
pathway are being developed. We aimed to investigate the effects of vericiguat, an sGC …
pathway are being developed. We aimed to investigate the effects of vericiguat, an sGC …
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms
Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a
second messenger involved in memory formation, while heme-free sGC is inactive. Two …
second messenger involved in memory formation, while heme-free sGC is inactive. Two …
[HTML][HTML] sGC agonist BAY1021189 promotes thoracic aortic dissection formation by accelerating vascular smooth muscle cell phenotype switch
Thoracic aortic dissection (TAD) is common but lethal cardiovascular disease with high
mortality. This study aimed to expound whether and how sGC-PRKG1 signaling pathway …
mortality. This study aimed to expound whether and how sGC-PRKG1 signaling pathway …
Novel Insights into Changes in Gene Expression within the Hypothalamus in Two Asthma Mouse Models: A Transcriptomic Lung–Brain Axis Study
Patients with asthma experience elevated rates of mental illness. However, the molecular
links underlying such lung–brain crosstalk remain ambiguous. Hypothalamic dysfunction is …
links underlying such lung–brain crosstalk remain ambiguous. Hypothalamic dysfunction is …
Impact of vericiguat on baroreflex-mediated sympathetic circulatory regulation: an open-loop analysis
A Yokoi, T Kawada, S Yokota, M Kakuuchi… - Plos one, 2023 - journals.plos.org
Aims To quantify in vivo the effects of the soluble guanylate cyclase (sGC) stimulator,
vericiguat, on autonomic cardiovascular regulation in comparison with the nitric oxide (NO) …
vericiguat, on autonomic cardiovascular regulation in comparison with the nitric oxide (NO) …
Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling
The complex mechanism by which stress can affect sensory processes such as hearing is
still poorly understood. In a previous study, the mineralocorticoid (MR) and/or glucocorticoid …
still poorly understood. In a previous study, the mineralocorticoid (MR) and/or glucocorticoid …