Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …
to induce demyelination of specific brain structures and is widely used as model of multiple …
Progressive multiple sclerosis: from pathophysiology to therapeutic strategies
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …
involves demyelination and axonal degeneration. Although substantial progress has been …
Multiple sclerosis pathology
H Lassmann - Cold Spring Harbor perspectives …, 2018 - perspectivesinmedicine.cshlp.org
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to …
nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to …
Neuroinflammation in the central nervous system: Symphony of glial cells
Q Yang, J Zhou - Glia, 2019 - Wiley Online Library
Neuroinflammation in the central nervous system (CNS) is an important subject of
neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key …
neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key …
Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics
E Kamma, W Lasisi, C Libner, HS Ng… - Journal of …, 2022 - Springer
There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis
In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …
The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis
In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between
demyelination and remyelination can trigger progressive degenerative processes. The …
demyelination and remyelination can trigger progressive degenerative processes. The …
Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data
Multiple sclerosis (MS) can be divided into four phenotypes based on clinical evolution. The
pathophysiological boundaries of these phenotypes are unclear, limiting treatment …
pathophysiological boundaries of these phenotypes are unclear, limiting treatment …
Role of the innate and adaptive immune responses in the course of multiple sclerosis
Multiple sclerosis is a chronic disease of the CNS that leads to substantial disability in most
patients. The early phase is characterised by relapses and the later phase by progressive …
patients. The early phase is characterised by relapses and the later phase by progressive …
The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology
The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …