JAK-STAT signaling: from interferons to cytokines
From the‡ Departments of Microbiology and Medicine, Columbia University, New York, New
York 10032, § Departments of Pathology and Microbiology, New York University School of …
York 10032, § Departments of Pathology and Microbiology, New York University School of …
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding …
Abstract Background Solitary Fibrous Tumor (SFT) is a distinct soft tissue neoplasm
associated with NAB2-STAT6 gene fusion. It can involve a number of anatomic sites and …
associated with NAB2-STAT6 gene fusion. It can involve a number of anatomic sites and …
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
T Mchedlidze, M Waldner, S Zopf, J Walker, AL Rankin… - Immunity, 2013 - cell.com
Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality
and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is …
and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is …
STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges
GL Wong, SG Manore, DL Doheny, HW Lo - Seminars in cancer biology, 2022 - Elsevier
Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors
J Chmielecki, AM Crago, M Rosenberg, R O'Connor… - Nature …, 2013 - nature.com
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the
identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis …
identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis …
Activation of STAT6 by STING is critical for antiviral innate immunity
STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular
cytokines. We now show that STAT6 is required for innate immune signaling in response to …
cytokines. We now show that STAT6 is required for innate immune signaling in response to …
Transcriptional regulation by STAT6
S Goenka, MH Kaplan - Immunologic research, 2011 - Springer
Signal transducer and activator of transcription (STAT) proteins are critical mediators of
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …
[HTML][HTML] The potential and controversy of targeting STAT family members in cancer
Abstract The Signal Transducer and Activator of Transcription (STAT) family of proteins
consists of transcription factors that play a complex and essential role in the regulation of …
consists of transcription factors that play a complex and essential role in the regulation of …
Programmed death ligand 2 in cancer‐induced immune suppression
Inhibitory molecules of the B7/CD28 family play a key role in the induction of immune
tolerance in the tumor microenvironment. The programmed death‐1 receptor (PD‐1), with its …
tolerance in the tumor microenvironment. The programmed death‐1 receptor (PD‐1), with its …
The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor α1 (IL13Rα1)
RT Martinez-Nunez, F Louafi… - Journal of Biological …, 2011 - ASBMB
Macrophages play a central role in the balance and efficiency of the immune response and
are at the interface between innate and adaptive immunity. Their phenotype is a delicate …
are at the interface between innate and adaptive immunity. Their phenotype is a delicate …