The rise of boron-containing compounds: advancements in synthesis, medicinal chemistry, and emerging pharmacology

RJ Grams, WL Santos, IR Scorei… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Bioactive glasses: from parent 45S5 composition to scaffold-assisted tissue-healing therapies

E Fiume, J Barberi, E Verné, F Baino - Journal of functional biomaterials, 2018 - mdpi.com
Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing
process of osseous defects deriving from traumatic events, tumor removal, congenital …

The physiological role of boron on health

H Khaliq, Z Juming, P Ke-Mei - Biological trace element research, 2018 - Springer
Boron is an essential mineral that plays an important role in several biological processes.
Boron is required for growth of plants, animals, and humans. There are increasing …

Effects of thirty elements on bone metabolism

M Dermience, G Lognay, F Mathieu… - Journal of Trace Elements …, 2015 - Elsevier
The human skeleton, made of 206 bones, plays vital roles including supporting the body,
protecting organs, enabling movement, and storing minerals. Bones are made of organic …

Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1)

SS Hakki, BS Bozkurt, EE Hakki - Journal of Trace Elements in Medicine …, 2010 - Elsevier
The aim of this study was to determine the effects of boron (B) on the cell-survival,
proliferation, mineralization and mRNA expression of mineralized tissue-associated …

Whole bone mechanics and bone quality

JH Cole, MCH van der Meulen - Clinical Orthopaedics and Related …, 2011 - Springer
Background The skeleton plays a critical structural role in bearing functional loads, and
failure to do so results in fracture. As we evaluate new therapeutics and consider treatments …

Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines

MR Naghii, M Mofid, AR Asgari, M Hedayati… - Journal of trace …, 2011 - Elsevier
Boron possesses widespread properties in biochemistry and nutrition. Acute
supplementation with 11.6 mg of boron resulted in a significant increase in plasma boron …

Growing evidence for human health benefits of boron

FH Nielsen, SL Meacham - Journal of Evidence-Based …, 2011 - journals.sagepub.com
Growing evidence from a variety of experimental models shows that boron is a bioactive and
beneficial (perhaps essential) element for humans. Reported beneficial actions of boron …

Effects of boron-containing compounds on liposoluble hormone functions

E Estevez-Fregoso, A Kilic, D Rodríguez-Vera… - Inorganics, 2023 - mdpi.com
Boron-containing compounds (BCC), particularly boronic acids and derivatives, are being
increasingly tested as diagnostic and therapeutic agents. Some effects of BCC involve …

Preparation and characterization of graphene oxide reinforced PVA film with boric acid as crosslinker

J Chen, Y Li, Y Zhang, Y Zhu - Journal of Applied Polymer …, 2015 - Wiley Online Library
ABSTRACT PVA films were prepared through aqueous solution method, and boric acid (BA)
as well as graphene oxide (GO) was added to improve the mechanical and thermal …