[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
Nuclear compartmentalization as a mechanism of quantitative control of gene expression
Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
Ten principles of heterochromatin formation and function
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …
particular genomic domains with specific functional properties. The capacity of …
The mammalian epigenome
Chemical modifications to DNA and histone proteins form a complex regulatory network that
modulates chromatin structure and genome function. The epigenome refers to the complete …
modulates chromatin structure and genome function. The epigenome refers to the complete …
The diverse functions of histone lysine methylation
C Martin, Y Zhang - Nature reviews Molecular cell biology, 2005 - nature.com
Covalent modifications of histone tails have fundamental roles in chromatin structure and
function. One such modification, lysine methylation, has important functions in many …
function. One such modification, lysine methylation, has important functions in many …
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
KL Yap, S Li, AM Muñoz-Cabello, S Raguz, L Zeng… - Molecular cell, 2010 - cell.com
Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …
Regulation of nucleosome dynamics by histone modifications
Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to
DNA, and chemical modification of histones is a major means by which the cell modulates …
DNA, and chemical modification of histones is a major means by which the cell modulates …
Mechanisms of polycomb gene silencing: knowns and unknowns
JA Simon, RE Kingston - Nature reviews Molecular cell biology, 2009 - nature.com
Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …
Perceiving the epigenetic landscape through histone readers
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Histones comprise the major protein component of chromatin, the scaffold in which the
eukaryotic genome is packaged, and are subject to many types of post-translational …
eukaryotic genome is packaged, and are subject to many types of post-translational …