An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …

Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the
genomic alterations present in tumours and has been used to monitor tumour progression …

Metastasis, involving the spread of systemic cancer to the brain, results in neurologic
disability and death. Current treatments are largely palliative in nature; improved therapeutic …

Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of
breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are …

Advances in chemotherapy and targeted therapies have improved survival in cancer
patients with an increase of the incidence of newly diagnosed brain metastases (BMs) …

The calcium signal is implicated in a variety of processes important in tumor progression (eg
proliferation and invasiveness). The calcium signal has also been shown to be important in …

The molecular events and transcriptional plasticity driving brain metastasis in clinically
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …

High-level folding of chromatin is a key determinant of the shape and functional state of
chromosomes. During cell division, structural maintenance of chromosome (SMC) …