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Azoreductase: a key player of xenobiotic metabolism
Azoreductases are diverse flavoenzymes widely present among microorganisms and higher
eukaryotes. They are mainly involved in the biotransformation and detoxification of azo dyes …
eukaryotes. They are mainly involved in the biotransformation and detoxification of azo dyes …
Heteroatom–heteroatom bond formation in natural product biosynthesis
Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …
A fluorescent zirconium organic framework displaying rapid and nanomolar level detection of Hg (ii) and nitroantibiotics
The solvothermal reaction of ZrCl4 with a benzo [1, 2-b: 4, 5-b′] dithiophene-2, 6-
dicarboxylic acid (L1) linker molecule in the presence of a trifluoro acetic acid modulator …
dicarboxylic acid (L1) linker molecule in the presence of a trifluoro acetic acid modulator …
Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Arylamine N‐acetyltransferases (NAT s) are polymorphic drug‐metabolizing enzymes,
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …
An update on derivatisation and repurposing of clinical nitrofuran drugs
nitrofurans (NFs) have been in clinical use for over 60 years. These affordable drugs are
used for the treatment of a broad spectrum of diseases ranging from urinary tract infections …
used for the treatment of a broad spectrum of diseases ranging from urinary tract infections …
Why great mitotic inhibitors make poor cancer drugs
Chemotherapy is central to oncology, perceived to operate only on prolific cancerous tissue.
Yet, many non-neoplastic tissues are more prolific compared with typical tumors …
Yet, many non-neoplastic tissues are more prolific compared with typical tumors …
Azoreductases in drug metabolism
Azoreductases are flavoenzymes that have been characterized in a range of prokaryotes
and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of …
and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of …
[HTML][HTML] Significance of specific oxidoreductases in the design of hypoxia-activated prodrugs and fluorescent turn off–on probes for hypoxia imaging
E Janczy-Cempa, O Mazuryk, A Kania, M Brindell - Cancers, 2022 - mdpi.com
Simple Summary Hypoxia-activated prodrugs (HAPs), selectively reduced by specific
oxidoreductases under hypoxic conditions, form cytotoxic agents damaging the local cancer …
oxidoreductases under hypoxic conditions, form cytotoxic agents damaging the local cancer …
An ultra-stable Cadmium (II) coordination framework constructed from the new bi-functional ligand and application as fluorescent probe for acetylacetone and …
Y Li, JD An, TT Wang, YF Shi, JZ Huo, XX Wu, YY Liu… - Dyes and …, 2021 - Elsevier
In the last thirty years, light-emitting metal organic frameworks (MOFs) sensors have
attracted immense interest by scientists because these functional coordination materials …
attracted immense interest by scientists because these functional coordination materials …
Further investigations of nitroheterocyclic compounds as potential antikinetoplastid drug candidates
Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected
tropical diseases (slee** sickness, Chagas disease and leishmaniasis) relies exclusively …
tropical diseases (slee** sickness, Chagas disease and leishmaniasis) relies exclusively …