Patterning the vertebrate neuraxis

A Lumsden, R Krumlauf - Science, 1996 - science.org
Neuraxial patterning is a continuous process that extends over a protracted period of
development. During gastrulation a crude anteroposterior pattern, detectable by molecular …

Gynecologic cancers and non-coding RNAs: epigenetic regulators with emerging roles

ZS Razavi, V Tajiknia, S Majidi, M Ghandali… - Critical reviews in …, 2021 - Elsevier
Gynecologic cancers involve the female genital organs, such as the vulva, vagina, cervix,
endometrium, ovaries, and fallopian tubes. The occurrence and frequency of gynecologic …

Segmentation and patterning of the vertebrate hindbrain

R Krumlauf, DG Wilkinson - Development, 2021 - journals.biologists.com
During early development, the hindbrain is sub-divided into rhombomeres that underlie the
organisation of neurons and adjacent craniofacial tissues. A gene regulatory network of …

Transcriptional Regulation and Implications for Controlling Hox Gene Expression

Z Afzal, R Krumlauf - Journal of Developmental Biology, 2022 - mdpi.com
Hox genes play key roles in axial patterning and regulating the regional identity of cells and
tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of Hox …

[HTML][HTML] Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest

HJ Parker, I Pushel, R Krumlauf - Developmental biology, 2018 - Elsevier
The neural crest is a transient population of cells that forms within the develo** central
nervous system and migrates away to generate a wide range of derivatives throughout the …

Hox genes: Downstream “effectors” of retinoic acid signaling in vertebrate embryogenesis

C Nolte, B De Kumar, R Krumlauf - genesis, 2019 - Wiley Online Library
One of the major regulatory challenges of animal development is to precisely coordinate in
space and time the formation, specification, and patterning of cells that underlie elaboration …

circEIF4G2 modulates the malignant features of cervical cancer via the miR‑218/HOXA1 pathway

Y Mao, L Zhang, Y Li - Molecular Medicine Reports, 2019 - spandidos-publications.com
Circular RNAs (circRNAs) serve important roles in tumorigenesis and may be used as novel
molecular biomarkers for clinical diagnosis. However, the role and molecular mechanisms of …

A Hox gene regulatory network for hindbrain segmentation

HJ Parker, R Krumlauf - Current topics in developmental biology, 2020 - Elsevier
In vertebrates, the hindbrain serves as a highly conserved complex coordination center for
regulating many fundamental activities of the central nervous system, such as respiratory …

A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates

HJ Parker, B De Kumar, SA Green, KD Prummel… - Nature …, 2019 - nature.com
In jawed vertebrates (gnathostomes), Hox genes play an important role in patterning head
and jaw formation, but mechanisms coupling Hox genes to neural crest (NC) are unknown …

A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation

D Segal, S Coulombe, J Sim, J Dostie - RNA biology, 2023 - Taylor & Francis
ABSTRACT HOTAIRM1 is unlike most long non-coding RNAs in that its sequence is highly
conserved across mammals. Such evolutionary conservation points to it having a role in key …